Instead of playing what is fashionable, play what is timeless. Avoid gimmicky first moves like 1. f4, 1. b3 and so on. The problem with these openings isn't that they are bad, but rather that they will restrict you to a very narrow range of position types. Strive to play as many different middlegame tabiyahs as possible. The chess player who studies openings - all openings, the opening in general - will see the similarities in otherwise distinct lines and learn to appreciate the similar rules that govern them.
So...
Play 1. e4. Play the open Sicilian. Otherwise, why play 1. e4? Attack. It's a great idea to play the 1.e4 e5 open games when you start out. Playing the white side of the Two Knights defence, for instance, will teach you about the balance struck between a perfectly intact pawn structure for one side and freedom and a lead in development for the other. But before long you should learn the Ruy Lopez. Even if the quantity and nature of the theory are daunting, and many lines offer black equality, you will usually have a space advantage which makes it a difficult equality for black. You have a blueprint of thousands of brilliant games played by the world's best players to study. Better to learn it now and then switch back to something less labyrinthine later in your playing career, as the longer you leave it, the harder it will be to embed all that information in your memory.
Or...
Play 1. d4. The Jobava London is hot right now, but the Queen's Gambit and the white side of the Indian defences are the chess equivalent of reading the classics. You will gain a vastly greater degree of transferable knowledge as a d4 player from following 1. d4 with 2. c4 than you would with any other second move. As you mature as a player, should you fall out of love with your original chosen lines you will find that you will not want for alternatives in the Queen's Gambit Declined, Nimzo-Indian, King's Indian, Grunfeld et al. Furthermore, in the age of databases and chess engines, these mainlines will offer you greater wriggle room should you feel the need to vary or become more unpredictable. Varying will prove much easier than were you to play the Colle or London exclusively. Even with slightly more aggressive offbeat systems like the Trompowsky, general knowledge of closed positions gained from mainline Indian defences will transfer better to someday playing the Trompowsky than vice versa.
Or...
Play 1. c4. Ignore those who decry it as boring. Those players hate facing 1. c4 and would rather you didn't play it, for their sake. Examine the games of Garry Kasparov or Alexander Morozevich in the English if you want inspiration. Play the mainlines. You'll be variously pushing your f-pawn, looking to sacrifice the exchange, and expanding on the kingside. And you won't lose many. Black players, despite not enjoying facing it, do not spend enough time preparing to face it. Play it until either you become predictable or you get bored of it, then switch to e4 or d4.